Buy Glucosamine Chondroitin Msm
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Chondroitin, glucosamine, and MSM is a combination medicine that has been used in alternative medicine as a possibly effective aid in treating osteoarthritis, muscle damage caused by exercise, and other inflammatory joint disorders.
It is not certain whether chondroitin, glucosamine, and MSM is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. This product should not be used in place of medication prescribed for you by your doctor.
Chondroitin, glucosamine, and MSM is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.
It is not known whether chondroitin, glucosamine, and MSM passes into breast milk or if it could harm a nursing baby. Do not use this product without medical advice if you are breast-feeding a baby.
If you choose to use chondroitin, glucosamine, and MSM, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.
It may take up several weeks before your symptoms improve. Call your doctor if the condition you are treating with chondroitin, glucosamine, and MSM does not improve after a few weeks of treatment, or if your condition gets worse while using this product.
Glucosamine may increase the glucose (sugar) levels in your blood. If you have diabetes, you may need to check your blood sugar more often while taking this medication. You may also need to adjust your insulin dosage. If you need surgery, you may need to stop taking chondroitin, glucosamine, and MSM at least 2 weeks ahead of time. Do not change your dose or medication schedule without advice from your doctor.
This list is not complete. Other drugs may interact with chondroitin, glucosamine, and MSM, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this product guide.
Taking the ComplexThe combination of chondroitin, glucosamine and MSM is used to support healthy joints and taken to reduce pain in those with osteoarthritis and other inflammatory joint problems. If you choose to take the chondroitin, glucosamine and MSM complex.
Glucosamine is a component of connective tissue, cartilage and joints and chondroitin is an important part of cartilage tissue. In combination with MSM (methylsulfonylmethane) and vitamin C, which can contribute to normal collagen formation, the perfect mixture for your joints, tendons, ligaments, bones and cartilage - in the usual Vitamaze quality.
Glucosamine is a component of connective tissue, cartilage and joints and chondroitin is an important part of cartilage tissue. And as with any building block in our body, it can also be deficient. Glucosamine and chondroitin are therefore present in high doses in the capsules.
Background: Glucosamine, chondroitinsulfate are frequently used to prevent further joint degeneration in osteoarthritis (OA). Methylsulfonylmethane (MSM) is a supplement containing organic sulphur and also reported to slow anatomical joint progressivity in the knee OA. The MSM is often combined with glucosamine and chondroitin sulfate. However, there are controversies whether glucosamine-chondroitin sulfate or their combination with methylsulfonylmethane could effectively reduce pain in OA. This study is aimed to compare clinical outcome of glucosamine-chondroitin sulfate (GC), glucosamine-chondroitin sulfate-methylsulfonylmethane (GCM), and placeboin patients with knee osteoarthritis (OA) Kellgren-Lawrence grade I-II.
Methods: a double blind, randomized controlled clinical trial was conducted on 147 patients with knee OA Kellgren-Lawrence grade I-II. Patients were allocated by permuted block randomization into three groups: GC (n=49), GCM (n=50), or placebo (n=48) groups. GC group received 1500 mg of glucosamine + 1200 mg of chondroitin sulfate + 500 mg of saccharumlactis; GCM group received 1500 mg of glucosamine + 1200 mg of chondroitin sulfate + 500 mg of MSM; while placebo group received three matching capsules of saccharumlactis. The drugs were administered once daily for 3 consecutive months VAS and WOMAC scores were measured before treatment, then at 4th, 8th and 12th week after treatment.
Conclusion: combination of glucosamine-chondroitinsulfate-methylsulfonylmethane showed clinical benefit for patients with knee OAK ellgren-Lawrence grade I-II compared with GC and placebo. GC did not make clinical improvement in overall groups of patients with knee OA Kellgren Lawrence grade I-II.
Glucosamine, chondroitin, and MSM are naturally existing chemicals found in the human body and in other natural sources. Glucosamine is an important building block for cartilage, while chondroitin is a structural component of cartilage that plays a role in shock absorption and elasticity. MSM is a form of sulfur, which the body uses to make collagen and support tissue healing. They are thought to help support healthy joint structure, comfort and function.
Studies show that glucosamine sulfate is readily absorbed into the body and can be traced to the cartilage as soon as four hours after consumption. However, the effects of glucosamine are cumulative, so it may take 30-90 days to experience the full benefit.
Glucosamine, chondroitin, and MSM are generally considered safe for most adults. But you should check with your doctor before use if you have high blood sugar, are pregnant or breastfeeding, or if you are taking any medications.
More recently, methylsulfonylmethane or MSM has been promoted as a possible supplement for osteoarthritis due to its suggested anti-inflammatory and analgesic effects.11 Similar to glucosamine and chondroitin sulfate, most MSM research has evaluated the effects of MSM supplementation on knee osteoarthritis, as Usha and Naidu12 and Kim et al13 both looked at the effects of 12-weeks of supplementation with methylsulfonyl-methane on knee osteoarthritis. In both studies, there was a significant difference between the supplementation and placebo group with the supplementation group showing decreased pain levels. In the study by Usha and Naidu12 specifically, when methylsulfonylmethane and glucosamine were combined there was a significant difference in swelling index, joint function, walking time, joint mobility index, and overall function ability when compared to the placebo and the supplements when taken individually.
The paper by Leffler et al17 received a score of 4/5 which corresponds with a good quality article16, with the only point missing being for the description of randomization method. Leffler et al compared the use of a combination of glucosamine, chondroitin, and manganese ascorbate with placebo for patients with degenerative joint disease of the knee or low back. The subjects were 34 males in the United States Navy with x-ray proven degenerative changes in the knees or low back. The 23 subjects with low back DJD were 43.6 years old on average. The subjects received either oral Cosamin (at a dosage of 1500 mg/day of glucosamine HCl, 1200 mg/day of chondroitin sulphate, and 228 mg/day of manganese ascorbate) or a matching placebo, each taken three times daily. Subjects spent three weeks in a baseline period, then received either 8 weeks of Cosamin or placebo, then crossed over to the other group for a final 8 weeks. Subjects were not permitted to take NSAIDs during the trial but they could take acetaminophen as necessary.
Thus, for the clinician there is contradictory evidence to support the use of glucosamine in the treatment of spinal osteoarthritis or disc degeneration based on the results of one positive study with low quality and one negative study with good quality. We identified no articles to support the use of chondroitin sulfate based on one negative study with good quality, or MSM based on no identified studies. Regardless, use of these supplements and their recommendation in practice is widespread.
A prospective cohort study of a random sample of 9423 Canadians found that 11.5% of their participants were taking glucosamine five years into the trial compared with 1.6% at baseline.23 This increased usage was associated with several factors including age, presence of arthritis and or back pain, calcium intake, regular physical activity, and use of glucosamine previously.23 The authors felt that some participants use glucosamine to manage the symptoms of arthritis and/or back pain, while others use it on a preventive basis.23 In 2007 glucosamine was the second most commonly used natural health product, used by 19.9% of participants over the previous thirty days in a survey of adults in the general population of the United States who used nonvitamin, nonmineral health products.24 In the same survey chondroitin was used by 11.9% of the participants, ranking eighth, while MSM was used by 4.1% of the participants, ranking eighteenth.24
For clinicians who do choose to recommend these supplements, it is important to bear in mind that there are some potential side-effects or contraindications to their use. It has been proposed that glucosamine sulfate could potentially alter glucose control, specifically interfering with the hexosamine biosynthesis pathway,25 and as such down-regulating cellular glucose uptake and leading to hypergylcemia and insulin resistance. To date, no effects on glucose concentrations were documented in studies evaluating the use of long-term oral glucosamine for osteoarthritis.9,26 Although no specific glucosamine sulfate induced changes in glycemic control are found in the literature, it should be noted that the subjects in these studies had well-controlled type II diabetes and it is unclear how glucosamine sulfate would affect individuals with type I diabetes who are unable to secrete additional endogenous insulin to compensate for the potential glucosamine-induced insulin resistance.27 Recently, a case report by Knudsen and Sokol addressed the effects of glucosamine sulfate on an individual utilizing warfarin.28 The authors suggested that the supplementation of glucosamine or glucosamine combined with chondroitin sulfate in individuals consuming warfarin could potentiate the anticoagulant effects of war-farin and thereby increase the risk of bleeding.28 Although this was only a case report, chiropractors should be cognizant of this potential glucosamine-warfarin interaction as some of the patients for whom they may consider a recommendation for glucosamine may be currently taking war-farin as an anti-coagulant. 59ce067264
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